File Name: epigenetic modifications and human disease .zip
- Role of Epigenetics in Biology and Human Diseases
- Epigenetics and Human Disease
- Epigenetics: Development and Disease
Cytosine guanine dinucleotide CpG island methylation is a known mechanism of epigenetic inheritance in postmeiotic cells. Through associated chromatin changes and silencing, such epigenetic states can influence cellular physiology and affect disease risk and severity.
Role of Epigenetics in Biology and Human Diseases
Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience. Skip to main content Skip to table of contents.
Genetic causes for human disorders are being discovered at an unprecedented pace. A growing subclass of disease-causing mutations involves changes in the epigenome or in the abundance and activity of proteins that regulate chromatin structure. This article focuses on research that has uncovered human diseases that stem from such epigenetic deregulation. Disease may be caused by direct changes in epigenetic marks, such as DNA methylation, commonly found to affect imprinted gene regulation. Also described are disease-causing genetic mutations in epigenetic modifiers that either affect chromatin in trans or have a cis effect in altering chromatin configuration. The last two decades have witnessed unparalleled success in identifying the genetic bases for hundreds of human disorders and, more recently, via sequencing, the whole exome or genome.
Metabolic chronic diseases, also named noncommunicable diseases NCDs , are considered multifactorial pathologies, which are dramatically increased during the last decades. Noncommunicable diseases such as cardiovascular diseases, obesity, diabetes mellitus, cancers, and chronic respiratory diseases markedly increase morbidity, mortality, and socioeconomic costs. Moreover, NCDs induce several and complex clinical manifestations that lead to a gradual deterioration of health status and quality of life of affected individuals. Multiple factors are involved in the development and progression of these diseases such as sedentary behavior, smoking, pollution, and unhealthy diet. Indeed, nutrition has a pivotal role in maintaining health, and dietary imbalances represent major determinants favoring chronic diseases through metabolic homeostasis alterations. In particular, it appears that specific nutrients and adequate nutrition are important in all periods of life, but they are essential during specific times in early life such as prenatal and postnatal phases. Indeed, epidemiologic and experimental studies report the deleterious effects of an incorrect nutrition on health status several decades later in life.
Epigenetics and Human Disease
Chapter Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases.
Epigenetics: Development and Disease
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurodegenerative and psychological disorders. This review first explains the history and classification of epigenetic modifications, and then the role of epigenetic in biology and connection between the epigenetics and environment are explained. Furthermore, the role of epigenetics in human diseases is considered by focusing on some diseases with some complicated features, and at the end, we have given the future perspective of this field.
Skip to search form Skip to main content You are currently offline.
Ты представляешь, что произойдет, если выйдет из строя система охлаждения ТРАНСТЕКСТА. Бринкерхофф пожал плечами и подошел к окну. - Электроснабжение уже наверняка восстановили. - Он открыл жалюзи. - Все еще темно? - спросила Мидж.
Она посмотрела на вентиляционный люк и принюхалась. Но запах шел не оттуда, его источник находился где-то поблизости. Сьюзан посмотрела на решетчатую дверь, ведущую в кухню, и в тот же миг поняла, что означает этот запах. Запах одеколона и пота. Она инстинктивно отпрянула назад, застигнутая врасплох тем, что увидела.
Человек, сидевший рядом, посмотрел на него в недоумении: так не принято было вести себя в храме Божьем. - Enferno, - извиняясь, сказал Беккер. - Я плохо себя чувствую. - Он знал, что должен буквально вдавиться в пол. И вдруг увидел знакомый силуэт в проходе между скамьями сбоку.