The Pathogenesis Diagnosis And Treatment Of Raynaud Phenomenon Pdf

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Correspondence Address : Dr. Raynaud's phenomenon RP is a multi-etiological vasospastic condition requiring individualized treatment. This case presents a patient with classic primary RP whose symptoms improved after being treated for depression.

Raynaud's phenomenon. Correspondence to. Raynaud's phenomenon RP is an episodic vasospasm of the peripheral arterioles, causing pallor followed by cyanosis and redness of the fingers and toes, usually in response to stress or cold exposure.

Pathophysiology of Raynaud's Disease

Here, we report a case of a year-old female diagnosed with PRP 7 years ago. Treatment with first-line agents, including calcium channel blocker, aspirin, and phosphodiesterase inhibitor, did not control her symptoms, which progressed to digital ulceration and gangrene. There were no symptoms of underlying autoimmune disease or malignancy, and autoimmune, serology, and immunology test results were normal; a biopsy of her left little finger was negative for vasculitis. Development to critical digital ischemia necessitated treatment with intravenous iloprost and heparin infusion followed by angioplasty, which led to a partial improvement. Due to persistent symptoms, rituximab therapy was initiated and two cycles induced a complete resolution of symptoms. PRP is typically a benign condition with an estimated prevalence of 4.

Severe Primary Raynaud’s Disease Treated with Rituximab

Vasospasm implies reversible vasoconstriction that may diminish blood flow to supplied tissues. Initially described by Maurice Raynaud in , episodic vasospastic ischemia of the digits characterizes Raynaud's phenomenon ; the idiopathic variety is termed Raynaud's disease. The typical acute attack comprises sequential phases of digital pallor, cyanosis, and rubor induced by cold or emotive stimuli. The well-demarcated pallor of a part or all of one or more digits during an episode of vasospasm is presumed to derive from spastic constriction of the digital arteries or arterioles, while subsequent cyanosis is attributed to retarded blood flow in dilated capillaries and venules. After a period of minutes to several hours, local rubor develops as a consequence of reactive hyperemia. In some patients only pallor or cyanosis occurs.

Raynaud's Phenomenon

The Raynaud phenomenon is a clinical disorder, characterized by episodic attacks of vasospasm of peripheral arteries and arterioles, causing tissue ischemia of distal portions of the body, such as hands and feet, causing changes in skin color such as pallor, cyanosis and hyperemia. The occurrence of the Raynaud phenomenon in people who handle organic sol vents or vibratory tools has been associated for a long time, and it has even been described that the solvents may be triggering some immune diseases such as scleroderma, however, as far as we know there are reports of exposure of chemical compounds used in metallurgy, such as nitric acid and the development of scleroderma-spectrum diseases. This article presents a clinical case related to the appearance of Raynaud s phenomenon against exposure to chemical compounds used in metallurgy, especially nitric acid. Key words: Raynaud's phenomenon; Nitric acid; Organic solvents; Capillaroscopy; Scleroderma spectrum disorders; Scleroderma pattern.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The past 10 years have seen the publication of results from several multicentre clinical trials in primary and systemic sclerosis SSc -related Raynaud phenomenon.

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Estos mecanismos descritos han impactado directamente en el desarrollo de nuevas terapias para el control de la enfermedad.. It is a frequent syndrome found in medical practice; and it can be considered as primary or secondary to other conditions, including rheumatic autoimmune diseases. Current classification had clinical and therapeutic implications. Such advances are directing new lines of therapy.. ISSN: X. Descargar PDF.

The pathogenesis of Raynaud's phenomenon is not fully understood. A key point is that Raynaud's phenomenon can be either primary idiopathic or secondary to a number of underlying conditions, and that the pathogenesis and pathophysiology vary between these conditions. This review concentrates upon those subtypes of Raynaud's phenomenon of most interest to rheumatologists: systemic sclerosis-related Raynaud's phenomenon, primary Raynaud's phenomenon and Raynaud's phenomenon secondary to hand—arm vibration syndrome. Vascular abnormalities include those of both structure and function. Intravascular abnormalities include platelet activation, impaired fibrinolysis, increased viscosity and probably oxidant stress.

 Espera! - крикнул он ему вдогонку. Его туфли кордовской кожи стучали по асфальту, но его обычная реакция теннисиста ему изменила: он чувствовал, что теряет равновесие. Мозг как бы не поспевал за ногами. Беккер в очередной раз послал бармену проклятие за коктейль, выбивший его из колеи. Это был один из старых потрепанных севильских автобусов, и первая передача включилась не. Расстояние между Беккером и ним сокращалось.

Evidence-based management of Raynaud’s phenomenon

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На экране ВР у входа толпились и множились хакеры, число их за последние минуты удвоилось. Теперь оно начало расти в геометрической прогрессии. Хакеры подобны гиенам: это одна большая семья, радостно возвещающая о любой возможности поживиться. Лиланд Фонтейн решил, что с него довольно этого зрелища.

ГЛАВА 32 Дэвид Беккер остановился в коридоре у номера 301. Он знал, что где-то за этой витиеватой резной дверью находится кольцо. Вопрос национальной безопасности. За дверью послышалось движение, раздались голоса.

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