Hyaluronic Acid And Skin Wound Healing And Aging Pdf

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Published: 18.06.2021

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Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture.

Why Science Says Hyaluronic Acid Is the Holy Grail to Wrinkle-Free, Youthful Hydration

Kasztanowa 3, Sosnowiec, Poland. Jednosci 8, Sosnowiec, Poland. Wound healing is the physiologic response to tissue trauma proceeding as a complex pathway of biochemical reactions and cellular events, secreted growth factors, and cytokines. Extracellular matrix constituents are essential components of the wound repair phenomenon. Firstly, they create a provisional matrix, providing a structural integrity of matrix during each stage of healing process. Currently known mechanisms, by which extracellular matrix components modulate each stage of the process of soft tissue remodeling after injury, have been discussed. Wound healing is a complex, biological process which concerns replacing damaged tissue by a living one [ 1 — 3 ].

Hyaluronic acid: A key molecule in skin aging

The aim of our work was to study the role of HA molecular weight in the proliferative phase of wound healing and to understand how this physiological biopolymer acts to promote wound healing on a human keratinocyte in vitro model. Our study showed that medium hyaluronan fragment MMW-HA, between and kDa induced a significant increase in wound closure, increased ZO-1 protein expression and induced a slight activation of P2X7 receptor, contrary to high between and kDa and low between 5 and 20 kDa molecular hyaluronan fragments that had no healing effects. Basal activation of P2X7 receptor is already known to stimulate cell proliferation and this activation in our model plays a pivotal role in MMW-HA-induced wound healing. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There are no patents, products in development or marketed products to declare.

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The Role of the Extracellular Matrix Components in Cutaneous Wound Healing

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К зарубежной агентурной сети. Им станут известны имена и местонахождение всех лиц, проходящих по федеральной программе защиты свидетелей, коды запуска межконтинентальных ракет. Мы должны немедленно вырубить электроснабжение. Немедленно.

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5 Response
  1. Angelika F.

    Hyaluronic acid also known as hyaluronan or hyaluronate is naturally found in many tissues and fluids, but more abundantly in articular cartilage and synovial fluid SF.

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